Nootropic Effect of Berberine in Colchicines Induced Experimental Alzheimer’s Disease Model: Effect on Cholinergic Neurotransmission
Authors: Shubhada V. Mangrulkar, Rohini D. Selote, Dinesh R. Chaple, Heena M. Upadhye
Abstract
Background & Objectives: Colchicine administration by ICV is well known model which shows sporadic dementia of the Alzheimer type in humans, causing cognitive impairment and oxidative damage. Berberine (BBR) is a naturally occurring flavonoid. Literature suggests multiple activities berberine. Hence it may act as a promising agent to combat AD. The present study has been designed to investigate the protective effects of berberine against the colchicine-induced cognitive impairment by modulating cholinergic neurotransmission in mice.
Docking of Hematoporphyrin on Various Anticancer Drugs Targeting Enzymes
Authors: Nandhini S, Radha R, Vadivu R
Abstract
The present study deals with docking of Hematoporphrin with various anticancer drugs targeting enzymes. The targets used were PDB-ID 2Y3I, PDB-ID 3OZZ, PDB-ID 3UEN and PDB-ID 4O33. Hematoporphyrin docked with these enzymes and interactions between the enzyme and compound were measured and compared with standard Paclitaxel. The study concluded that, the compound (Hematoporphyrin) isolated from plant were high interactions with PDB-ID 4O33 when compared to standard.
Formulation and Evaluation of Cinitapride Controlled Release Tablets
Authors: Mercy Mathew, Ravikumar, Simila Madathil, Anju Govind, Narayana Swamy VB
Abstract
The present study aimed at Formulation Development and Evaluation of controlled release tablets of Cinitapride for the treatment of ulcer. Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class. It act as an agonist of the 5- HT1 and 5- HT4 receptors and an antagonist of the 5- HT2 receptors. It is used in the treatment of gastrointestinal disorders associated with motility disturbances such as gastro esophageal reflux disease, non- ulcer dyspepsia and delayed gastric emptying. The matrix tablets of Cinitapride were prepared using wet granulation. Physical characterization of tablet and powder blends used to form the matrix tablet was under taken using a range of experimental techniques. Granules were evaluated for Bulk density, Tapped density, Compressibility index and Hausner’s ratio. Tablets were tested for weight variation, hardness, thickness and friability as per official procedure. The tablets were evaluated for in-vitro drug release profile. Dissolution studies of Cinitapride controlled release tablets in media with different dissolution media 0.1N HCl, Phosphate buffer pH (6.8) as per US Pharmacopoeia. The dissolution data revealed that the ratio of polymers is very important to achieve a optimum formulation. The formulation of Cinitapride CR tablets shown that formulation F23 with Methocel K100M (20%) shown good drug release profile. Formulation F23, shown similar dissolution profile when compared with the marketed product (Cintapro). Stability study of the formulation F23 indicated no significant difference in release profile after a period of 3 months.