Development and Validation of Difference Spectroscopic Method for Citicoline Sodium in Tablet Dosage Forms by Ultraviolet Spectroscopy
Authors: Asma A. Pathan, Prajakta S. Pattanshetty, Arwa A. Koita
Abstract
Simple, sensitive and specific spectrophotometric method was developed and validated for quantification of Citicoline Sodium by difference spectroscopy method. Citicoline sodium exhibits a substantial difference in absorbance in the two solvents that is in 0.01 N HCL and 0.01 N NaOH at 283 nm. Beer’s law was obeyed in the concentration range of 5 to 50 μg/ml. Results of tablet analysis showed assay value ranging 98 % to 100 % with standard deviation of 0.85 for Citicoline Sodium which indicates repeatability of the method. The results indicated excellent recoveries ranging from 96 % to 103.9 % for Citicoline Sodium with mean of 100 %. Method was validated according for all method parameters for assay as per ICH guidelines Q2R1. Developed method was found to be accurate, linear, precise, sensitive, robust and rugged as per ICH Q2R1 guidelines.
Performance Analysis of Bitumen Mixtures Using Nano - Sio2 Powder
Authors: Pappu Kumar, Kapil Soni
Abstract
Nano-particles are widely used to improve the high temperature performance of bituminous binders. However, the influence of humidity on performance at high temperatures is not clear. Therefore, the water absorption capacity of nano-SiO2 modified asphalt concrete is examined. Based on, Bitumen with a black surface faces problems, especially cracks and ruts. These deformations occur in Bitumens due to defects in the mix attributes and increased traffic loads. They occurred due to the lack of black cover and, in addition, due to mixing. This article focuses on how to improve the qualities of superior black mixes using Nano-SiO2 Powder (NSP). The exploration includes the study of the properties of mixtures modified using NSP. The NSP substances tested represent 2, 4, 6, 8 and 10% of the weight of the bitumen. Marshall, Retention Marshall, Indirect Tensile Test (ITS) and penetration and softening point tests are used to evaluate the properties obtained. The results show that the most suitable NSP content is 6% by weight of the black tip. A 6% NSP variation in the Black-Top compound increases Marshall strength by 33.56%, decreases penetration by 8.32%, and creates conditioning by 11.22%, providing a ratio of unit weight to approximately similar air gap and other properties of the mixture are maintained as much as possible. possible. The broad inclusion of NS results in the improvement of the properties of the black coating compounds.
A Review on Implementation of Affiliate Trading Platform Using Consumer Response
Authors: Vrushali Shrawan Thombre, Vaibhav Ashok Dharnidhar, Pratiksha Nirvikar Adhau, Ankita Sanjay Dhunde, Prof. Sharadha Chourasia
Abstract
The rapid development of affiliate marketing, a performance based internet marketing practice, in the recent years has created a very competitive market. Companies need to constantly improve their affiliate programs to maintain a successful program and to keep affiliates loyal. Affiliate programs are a type of marketing where the partners or affiliates advertise products in several websites, social media platforms this type of marketing is based on performance, since compensation is usually calculated through the amount of clicks. The goal of proposed work is to build a functioning affiliate program for small retailers.