Attenuation of Depressant Activity by Ethanol Extract of Seeds of Areca Catechu in Swiss Albino Mice After Deca - Days Administration
Authors: Srinivas Bhat U, Sharath Kumar K, Rashmi R Rao, Chandrashekar R, Mohandas Rai
Abstract
Depression is the loss of ability to enjoy life and experience pleasure. The symptoms are constant, ranging from moderate to severe. If untreated, major depression typically lasts for about six months. Some people experience just a single depressive episode in life. The objective of the present study was to evaluate attenuation of depressant activity by Ethanolic extract of seeds of Areca catechu in Swiss Albino mice after deca day’s administration. Animals were randomly allocated into five groups comprising six animals in each. Group I was treated with normal saline (0.1 ml/10 g) which served as control. Group II was treated with Imipramine at the dose of 10 mg/kg which served as standard. Groups II, IV and V were treated with three different doses (40, 80, and 160 mg/kg) of Ethanolic extract of seeds of Areca catechu. All the drugs were given intraperitonially (0.1 ml/10 g) daily for 9 days and 30min before the experiment on the 10th day. Ethanolic extract of seeds of Areca catechu has shown significant antidepressant activity at all the doses but more evident at the dose of 80mg/kg which was comparable with Imipramine 10mg/kg by forced swim test and tail suspension test.
Mechanisms, Methods of Detection and Causality Assessment of Adverse Drug Reactions
Authors: Akshay Sadhotra, Anshu Gupta, Rani Walia, Nidhi Sharma
Abstract
Adverse Drug Reactions are very common cause of hospital morbidity.
To Compare The Efficacy and Safety Eperisone with Thiocolchicoside in Patients with Acute Lower Backache Associated with Muscle Spasm
Authors: Seema Rani, Sanjeev Kumar, Joyti, Prem Kumar Vaerma, Dharvin Lamba, Rahul Saini
Abstract
Background & Objectives: Eperisone hydrochloride is a new drug came in market with centrally acting muscle relaxant, having additional vasodilator effect and used for treatment of backache associated with muscle stiffness like thiocolchicoside but supposed to be slightly better in efficacy and adverse effect profile. The aim of this study was to compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm.
The Study of Detecting Replicate Documents Using MD5 Hash Function
Authors: Pushpendra Singh Tomar, Maneesh Shreevastava
Abstract
A great deal of the Web is replicate or near- replicate content. Documents may be served in different formats: HTML, PDF, and Text for different audiences. Documents may get mirrored to avoid delays or to provide fault tolerance. Algorithms for detecting replicate documents are critical in applications where data is obtained from multiple sources. The removal of replicate documents is necessary, not only to reduce runtime, but also to improve search accuracy. Today, search engine crawlers are retrieving billions of unique URL’s, of which hundreds of millions are replicates of some form. Thus, quickly identifying replicate detection expedites indexing and searching. One vendor’s analysis of 1.2 billion URL’s resulted in 400 million exact replicates found with a MD5 hash. Reducing the collection sizes by tens of percentage point’s results in great savings in indexing time and a reduction in the amount of hardware required to support the system. Last and probably more significant, users benefit by eliminating replicate results. By efficiently presenting only unique documents, user satisfaction is likely to increase.
Fast Dissolving Oral Films
Authors: S.B. Gondkar, Namrata D. Patil, R.B. Saudagar
Abstract
The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Oral fast dissolving films is relatively a new dosage form in which thin film is prepared using hydrophilic polymers which rapidly dissolves on tongue or Buccal cavity. The films overcome the fear of chocking. An ideal film should have the properties like pleasant taste, high stability, ease of handling and administration, no water necessary for application. Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing.