Hepatoprotective and Anti Pyretic Activities of Methanolic Extract of Butea Monosperma Lam Stem Bark In Wister Rats
Authors: R. Sathish, P. Sravan Kumar, K. Natarajan, N. Sridhar
Abstract
The methanolic extract of stem bark of Butea monosperma Lam (MEBM) was studied for the hepatoprotective and antipyretic activities. Carbontetrachloride (1ml/kg, i.p) induced hepatotoxicity and Brewer’s yeast (10ml/kg, s.c) induced pyrexia rat models were used. The 10 days treatment of MEBM (200 mg/kg and 400 mg/kg, p.o) showed significant (P<0.01) hepatoprotective effect by dose dependent manner. The MEBM significantly (P<0.01) lowered the elevated levels of serum biochemical parameters such as SGOT, SGPT, ALP, total bilirubin and also significantly (P<0.01) increased total protein levels when compared to toxic control rats. The MEBM at both dose levels (200 mg/kg and 400mg/kg, p.o) produced significant (P<0.01) antipyretic activity throughout the observation period up to 6 h. The phytochemical analysis showed the presence of biologically active constituents such as flavonoids, glycosides and sterols. The flavonoids in the MEBM may be responsible for the significant hepatoprotective and antipyretic activities.
Multicell Z Source Inverter For Adjustable Speed Drives
Authors: Sibi Rahman T. P, Hareesh. A
Abstract
In this paper a Multicell Switched inductor Z- source inverter is proposed for adjustable speed drives (ASD). To increase the boosting flexibility a new topology is introduced by adding multiple cells of inductor and diode to the source side of the inverter, it results in the better performance than the conventional system. As the topological difference necessitates the change in switching control for the better performance SBC is employed. ZSI has the unique topological feature that it can act as a second order filter and there by reduces the harmonics and thus it achieves higher output profile.
Synthesis, Characterization and Its Biological Evaluation of Some Novel 4-Thiazolidinone and 2-Azetidinone Derivatives
Authors: P. Jaya Preethi, K. Bindu Sree, K. Pavan Kumar, R. Rajavelu and T. Sivakumar
Abstract
In the present study, a series of 4-thiazolidinones and 2-azetidinone derivatives were synthesized by refluxing Schiff bases with different aromatic aldehydes. Schiff bases were synthesized by reaction of nicotinamide with hydrazine hydrate. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analysis. These compounds were screened for anti-tubercular, anti-convulsant anti- bacterial and anti-fungal activities. Anti-Tubercular activity mycobacterium tuberculosis and MIC level of the compounds was less than 6.25 µg/ml. Compound IIIa, IIId, IVa and IVd exhibited good Anti-convulsant activity. Compound IIIa, IIIc IIId, IVa, IVc and IVd exhibited good antibacterial activity on Gram-positive and Gram-negative microorganisms. All the synthesized compounds exhibited good Antifungal activity.
Tuberculosis: A Brief Overview
Authors: Lalit Kumar, Rajan, Vivek Sharma
Abstract
Tuberculosis is an infectious disease that affects lungs simple it seems but it is among the first ten leading causes of mortality all over the world. It has been 50 years since the introduction of novel drug candidate for the treatment of tuberculosis and despite many efforts for the development of new antitubercular drug, the pharmaceutical industry has, with few exceptions, indicated little interest in undertaking work in this arena. This lack of interest is due to two key perceptions that currently available drugs are adequate for the control of tuberculosis and that sufficient monetry benefit could not be realized to justify the expense of bringing a new tuberculosis drug to market. This article presents a brief overview of existing drugs and the drug candidates which are under development.
Curry Leaves – A Medicinal Herb
Authors: Sinha Parul, Akhtar Javed , Batra Neha , Jain Honey , Bhardwaj Anuj
Abstract
Plants are one of the most important sources of medicines. Curry leaf (Murraya koenigii) is an important leafy vegetable. Its leaves are widely used in Indian cookery for flavouring foodstuffs. Curry leaf is Native to India. Large shrub to small tree. Pinnate leaves are used in many South Indian curries. The major constituents identified were the volatile oil of the fresh leaves of Murraya koenigii. Its nutritional value benefits both the young and the old alike. Women who suffer from calcium deficiency, osteoporosis etc can find an ideal natural calcium supplement in curry leaves. They are also used externally to cure eruptions and the bites of poisonous animals. Curry leaves can be used with effective result to treat burn, bruises and skin eruption. Kidney pain can be cured by using juice of root of Murrayakoenigii. It can be used in preventing premature greying of hair. A volatile oil, curry leaf oil, produced from the plant has uses in the soap industry.