Solid State Compatibility Study of Rice Bran Wax with Nifedipine for its Use in Pharmaceutical Products
Authors: Avish D. Maru, Prashant V. Bodhe, Rajendra K. Surawase
Abstract
Rice bran wax is a natural vegetable wax and is a value added by-product of Rice bran oil refineries. It is hard nontacky wax and contains higher fatty alcohols and esters which make it comparable to Carnauba wax. In the present work, studies are carried out on Rice bran wax for various physico-chemical properties like solubility, melting point, specific gravity, moisture content, saponification value, acid value, ester value, hydroxyl value, unsaponifiable matter, Iodine number etc. Moreover the solid state compatibility studies was carried out by using mixture of Nifedipine and RBW in the 1:1 ratio at 60° c for 15 days and observed for its physical changes i. e. discoloration, liquefaction, gas formation etc and chemical changes i.e. interaction in between Nifedipine and RBW. It was carried out by using Differential Scanning Colorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FT-IR). The result shows that there are no physical and chemical changes; therefore RBW can be used in formulations of Nifedipine.
Atomic Study on Fusarium Incarnatum Using Bioinformatics Tools
Authors: Madhanraj P, Ramanathan K, Arun N, Nadimuthu N, Panneerselvam A
Abstract
We have been investigating that the atomic study of Fusarium incarnatum with the utilization of Bioinformatics tools. We have been involved in the insilico study on the plant pathogen the Fusarium incarnatum. The involvement of Nucleotides and atoms in this species can be identified with the help of Bioinformatics tools. We can also involved in the analysis of amino acids which are present in this species and calculated the start and stop codons in different frames.
Hepatoprotective Activity of Aqueous Extract of Lawsonia Inermis Against Paracetamol Induced Rats
Authors: R. Selvanayaki, T. Ananthi
Abstract
The present study was conducted to evaluate the hepatoprotective activity of aqueous extract of Lawsonia inermis against paracetamol induced liver damage in rats. The aqueous extract of Lawsonia inermis was administered orally to the animals with hepatotoxicity induced by paracetamol. Silymarin was given as reference standard. The plant aqueous extract was effective in protecting the liver against the injury induced by Paracetamol in rats. This was evident from significant reduction in serum enzymes alkaline aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), Acid Phosphatase (ACP), Protein and Bilirubin. It was concluded from the result that the aqueous extract of Lawsonia inermis possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.